Evidence-based review program

Science-backed reviews of alternative and off-label ALS treatments

ALSUntangled® helps patients and families cut through the noise — rigorous, transparent evaluations to support more informed decisions.

treatments reviewed

evidence criteria

years of research

How we evaluate treatments using five transparent evidence criteria and expert grading.

All 88 treatments we’ve evaluated — searchable, filterable, with full grades and summaries.

You can vote

See what treatments are queued for review — and cast your vote for the ones that matter most to you.